Synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O

Authors

Takuya Okada, University of Toyama
Taiga Yamamoto, University of Toyama
Daiki Kato, University of Toyama
Masashi Kawasaki, Toyama Prefectural University
Ralph Saporito, John Carroll UniversityFollow
Naoki Toyooka,, University of Toyama

Document Type

Article

Publication Date

10-2018

Publication Title

Tetrahedron Letters

Abstract

The asymmetric synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O has been achieved, starting from both enantiomers of (+)- and (−)-10. Enantiomerically pure alcohols (+)- and (−)-10 were obtained by lipase-mediated kinetic resolution of racemic 10, which was prepared in 3 steps from new lactam-type building block (−)-8 in a highly stereoselective manner.

Recommended Citation

Okada, Takuya; Yamamoto, Taiga; Kato, Daiki; Kawasaki, Masashi; Saporito, Ralph; and Toyooka,, Naoki, "Synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O" (2018). 2018 Faculty Bibliography. 73.
https://collected.jcu.edu/fac_bib_2018/73

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