The asymmetric synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O has been achieved, starting from both enantiomers of (+)- and (−)-10. Enantiomerically pure alcohols (+)- and (−)-10 were obtained by lipase-mediated kinetic resolution of racemic 10, which was prepared in 3 steps from new lactam-type building block (−)-8 in a highly stereoselective manner.
Okada, Takuya; Yamamoto, Taiga; Kato, Daiki; Kawasaki, Masashi; Saporito, Ralph; and Toyooka,, Naoki, "Synthesis of 8-deoxypumiliotoxin 193H and 9-deoxyhomopumiliotoxin 207O" (2018). 2018 Faculty Bibliography. 73.
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