Hypoxia-inducible factor 1 alpha mediated regulation of mitochondrial function and homeostasis in normoxia
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During normal levels of oxygenation, also known as normoxia, the transcription factor hypoxia-inducible factor (HIF) 1α is produced and broken down in a continuous manner. Previous studies of HIF1α function(s) in hypoxia demonstrate restricted oxygen uptake and decreased protein synthesis but data regarding this transcription factor in normoxia is limited. We determined the functional aspects of HIF1α in normoxia in differentiated myotubes and with transgenic mice. Higher expression of sirtuin 3 along with higher concentrations of many TCA cycle intermediates were identified in multiple studies. Additionally, phenotypic and morphological implications of HIF1α in normoxia were identified.
Lunkis, Matthew, "Hypoxia-inducible factor 1 alpha mediated regulation of mitochondrial function and homeostasis in normoxia" (2023). Celebration of Scholarship 2023. 6.