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Publication Date

Spring 2017


Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies that target nuclear and cytoplasmic agents. Lupus manifests an array of symptoms and is estimated to affect more females than males. This study analyzed the effects of type 1 interferon deficiency on B-cells in lupus prone mice. Data indicates that specific B-cell IFNAR deficiency in lupus prone mice results in significantly lower spleen weight, splenocyte count, and anti-chromatin IgG levels. Funded by the Cleveland Clinic Summer Research Program.

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