The Hippo Pathway inactivates genes involved in organ size and when aberrant, can lead to cancer. To control organ size, the Hippo Pathway inhibits Yorkie (Yki), a transcriptional co-activator that works with Scalloped (Sd), a DNA binding protein. When active, Yki translocates into the nucleus and initiates transcription. Conversely, when inactive, Yki remains in the cytoplasm. However, my work shows that cytoplasmic, inactive Yki interacts with other proteins in the Hippo Pathway by recruiting them to the plasma membrane. Accordingly, this study challenges the notion that cytoplasmic Yki is inactive and instead, may play a dual role in the Hippo Pathway.
Hall, Caroline, "A Putative Dual Role for Yorkie in Hippo Pathway Signaling" (2016). Celebration of Scholarship. 5.